Everyone has an opinion on Ozempic. If you've scrolled through TikTok or listened to a podcast in the last two years, you’ve heard the whispers, the jokes, and the "judgmental" side-eyes. But for Claudia Oshry—the force behind Girl With No Job and co-host of The Toast—this wasn’t just a trending topic. It was her reality.
She lost 70 pounds.
That’s a massive number. It’s a whole person. But while the internet was busy obsessed with her "Ozempic face" or how she looked in a sports bra, Claudia was dealing with the actual, messy human side of a medical transformation. Honestly, the most interesting part isn’t even the weight loss itself—it’s the "now what?" phase that happens after the injections stop.
The Claudia Oshry Weight Loss Journey: Why She Started
In late 2022, Claudia made a choice. She was 25, out of breath just walking around, and felt like she couldn't sustain her own weight. It wasn't just about "looking skinny" for a red carpet. She has been vocal about wanting to start a family one day, and her health at the time was a major roadblock.
She started Ozempic in September 2022.
For a year, she kept it quiet. Why? Because of the shame. We live in a world that tells you to lose weight but then mocks you if you use the tools available to do it. Claudia eventually broke down in tears on her podcast, admitting she was "ashamed" she had let herself get to a point where she had 70 pounds to lose in the first place.
Breaking the Silence
When she finally came clean in August 2023, she didn't hold back. She basically told her audience, "You thought they were going to make a weight loss drug and I wasn't going to take it? You're dumb."
It was classic Claudia—blunt, funny, and deeply defensive of her right to medical privacy. But beneath the jokes was a real struggle with "Ozempic rebound" fears and the realization that her entire identity as a "fat comedian" was shifting.
Life After the Jab: The Reality of "Food Noise"
Claudia stopped taking Ozempic in November 2023. By March 2024, she was being incredibly candid about what happens when the medicine leaves your system.
The hunger came back.
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And it didn't just come back; it hit like a freight train. She posted a TikTok that went viral where she admitted to being "hungry all the motherf—king time." She described eating a 12 oz. steak and still feeling like she needed to reach for a bag of popcorn immediately after.
This is what doctors call "food noise."
When you're on a GLP-1 medication, that constant mental chatter about food—What's for lunch? Is there dessert? Am I bored or hungry?—basically shuts off. When you stop, the volume gets turned back up to 10.
The Physical Toll Nobody Mentions
It wasn't just the hunger. Claudia also dealt with significant hair shedding. She estimated it took about six to nine months for her hair to return to normal after she stopped the medication. To fight back, she went on a full-on hair-care mission:
- Nutrafol supplements.
- Minoxidil (standard hair growth treatment).
- Prenatal vitamins.
- Vegamour serum.
- Consistent quarterly haircuts to manage the thinness.
How She’s Actually Keeping the Weight Off in 2026
So, did she gain it all back? That’s the question everyone asks because studies (like those published in the British Medical Journal) suggest many people regain two-thirds of the weight within a year of stopping.
Claudia didn't.
She’s been off the medication for well over a year now, and she’s maintained that 70-pound loss. How? By basically doing the "boring" stuff that we all know works but is incredibly hard to do without a safety net.
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- High Protein is Non-Negotiable: She focuses on protein to stay full because, without the drug slowing her digestion, she has to use fiber and protein to do the heavy lifting.
- WeightWatchers (WW): She returned to a structured point system to keep her portions in check.
- Strength Training: She’s been hitting the gym. Building muscle is the only way to keep your metabolism from tanking after a major weight loss.
- Mental Shifts: In recent 2025 and 2026 interviews, like her deep dive with Jay Shetty, she talked about how she had to stop letting her body image hold her back.
The "Funny Fat Girl" Identity Crisis
One of the most nuanced things Claudia has discussed is her "writer's block." For years, her comedy was rooted in being the "fat girl." When she got skinny, she admitted she didn't know what to make jokes about anymore.
"I think a lot of people become funny because they're fat," she told ET. "It's like your only option."
Processing the way the world treats her now is also weird. She’s mentioned being stopped on the street by people who don't even say hello—they just yell "Congratulations!" about her body. It’s a "fluid situation," as she calls it. It's validating but also deeply uncomfortable to realize people like you more just because there's less of you.
Actionable Takeaways from the Claudia Oshry Story
If you’re looking at Claudia’s journey and wondering what it means for your own health, there are some very real lessons here that go beyond the celebrity gossip.
Manage the Transition Period
If you use a GLP-1, you need a "Plan B" for the day you stop. Claudia’s fear was being off it, but she survived by leaning into high-protein diets and structured programs like WeightWatchers immediately.
Watch for the Side Effects
Hair shedding and extreme hunger aren't "failures"—they are documented biological responses. Being prepared with a hair-care routine (like Minoxidil or Nutrafol) can save you a lot of stress.
Focus on "Food Noise" Management
Identify if your hunger is physical or mental. Claudia’s transparency shows that even with all the money and resources in the world, the mental battle with hunger is the hardest part.
Prioritize Muscle
Losing 70 pounds usually means losing muscle too. If you don't replace that muscle with strength training, your metabolism will stay slow, making regain almost inevitable.
Claudia’s story isn't a "magic pill" narrative. It’s a story about using a tool to get to a baseline of health and then working like crazy to stay there. It’s messy, it involves a lot of steak and popcorn, and it’s about as human as it gets.
Next Steps for Long-Term Maintenance:
To emulate a successful transition like Claudia's, focus on increasing your daily protein intake to at least 0.8g per pound of body weight and schedule a consultation with a nutritionist to create a "post-medication" caloric baseline. Building a consistent resistance training habit twice a week is also vital for preventing the metabolic slowdown associated with rapid weight loss.